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The correct functioning of the mammalian brain depends on t
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The correct functioning of the mammalian brain depends on the integrated activity of myriad neuronal and non-neuronal cells. Discrete areas serve discrete functions, and dispersed or distributed communities of cells serve others. Throughout, these networks of activity are under the control of neuromodulatory systems. One goal of current neuroscientific research is to elucidate the precise methods by which these systems operate, especially during normal conscious behaviours and processes. Mircea Steriade and Denis Paré describe the neuronal properties and networks that exist within and between the cortex and two important sub-cortical structures: the thalamus and amygdala. The authors explore the changes in these properties, covering topics including morphology, electrophysiology, architecture and gating; and comparing regions and systems in both normal and diseased states. Aimed at graduates and postdoctoral researchers in neuroscience.
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Over the last decade, the study of complex networks has exp
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Over the last decade, the study of complex networks has expanded across diverse scientific fields. Increasingly, science is concerned with the structure, behavior, and evolution of complex systems ranging from cells to ecosystems. Modern network approaches are beginning to reveal fundamental principles of brain architecture and function, and in Networks of the Brain, Olaf Sporns describes how the integrative nature of brain function can be illuminated from a complex network perspective. Highlighting the many emerging points of contact between neuroscience and network science, the book serves to introduce network theory to neuroscientists and neuroscience to those working on theoretical network models. Brain networks span the microscale of individual cells and synapses and the macroscale of cognitive systems and embodied cognition. Sporns emphasizes how networks connect levels of organization in the brain and how they link structure to function. In order to keep the book accessible and focused on the relevance to neuroscience of network approaches, he offers an informal and nonmathematical treatment of the subject. After describing the basic concepts of network theory and the fundamentals of brain connectivity, Sporns discusses how network approaches can reveal principles of brain architecture. He describes new links between network anatomy and function and investigates how networks shape complex brain dynamics and enable adaptive neural computation. The book documents the rapid pace of discovery and innovation while tracing the historical roots of the field. The study of brain connectivity has already opened new avenues of study in neuroscience. Networks of the Brain offers a synthesis of the sciences of complex networks and the brain that will be an essential foundation for future research.
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Over the last decade, the study of complex networks has exp
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Over the last decade, the study of complex networks has expanded across diverse scientific fields. Increasingly, science is concerned with the structure, behavior, and evolution of complex systems ranging from cells to ecosystems. Modern network approaches are beginning to reveal fundamental principles of brain architecture and function, and in Networks of the Brain, Olaf Sporns describes how the integrative nature of brain function can be illuminated from a complex network perspective. Highlighting the many emerging points of contact between neuroscience and network science, the book serves to introduce network theory to neuroscientists and neuroscience to those working on theoretical network models. Brain networks span the microscale of individual cells and synapses and the macroscale of cognitive systems and embodied cognition. Sporns emphasizes how networks connect levels of organization in the brain and how they link structure to function. In order to keep the book accessible and focused on the relevance to neuroscience of network approaches, he offers an informal and nonmathematical treatment of the subject. After describing the basic concepts of network theory and the fundamentals of brain connectivity, Sporns discusses how network approaches can reveal principles of brain architecture. He describes new links between network anatomy and function and investigates how networks shape complex brain dynamics and enable adaptive neural computation. The book documents the rapid pace of discovery and innovation while tracing the historical roots of the field. The study of brain connectivity has already opened new avenues of study in neuroscience. Networks of the Brain offers a synthesis of the sciences of complex networks and the brain that will be an essential foundation for future research.
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This book contains the latest development technologies in t
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This book contains the latest development technologies in the area of Power Systems. Deals with the deep-rooted linkages between existing and emerging concerns faced by distributed energy resources and their integration DESCRIPTION The conventional power system around the world is facing the problems of gradual depletion of fossil fuel resources, poor energy efficiency and environmental pollution. This has lead to the recent trend of generating power at distribution voltage level from renewable/non-conventional, small scale distributed energy resources (DERs) to culminate the advantages of improved energy efficiency, low emissions, better utilisation of eco-friendly energy sources, augmentation of low capital intensive generation, co-generation and tri-generation. However DERs suffer from the demerits of initial high cost, technical difficulties, absence of regulatory & marketing standards, lack of communication protocols, administrative & legal barriers, intermittent nature of generation etc. which are under extensive research worldwide. Technical development in the field of DERs is also resulting in the formation of MicroGrid (MG) & Active Distribution Networks (ADISNET). These are LV power supply networks comprising integrated DERs, designed to supply power to small community, operating either in synchronism with MV Regional Grid or as stand-alone systems. MG and ADISNET offer a potential solution for sustainable, energy-efficient power supply to cater for increasing load growth, supplying power to remote areas, generation of clean power and reduction in emission of greenhouse gases & particulates as per Kyoto protocol. CONTENTS DISTRIBUTED GENERATION AND MICROGRID CONCEPT Distributed Energy Sources Impacts of Microgrid Microgrid & Active Distribution Network Management System Protection Issues for Microgrids Power Electronic Interfaces SCADA & Active Distribution networks Impact of DG Integration on Power Quality and Reliability Microgrid Economics Market Participation of Microgrids - Appendices RELATED TITLES Distributed Generation 978-0-86341-958-4 (2009) Electricity Distribution Network Design 978-0-86341-309-4 (2003) The Institution of Engineering and Technology is one of the world's leading professional societies for the engineering and technology community. The IET publishes more than 100 new titles every year; a rich mix of books, journals and magazines with a back catalogue of more than 350 books in 18 different subject areas including: -Power & Energy -Renewable Energy -Radar, Sonar & Navigation -Electromagnetics -Electrical Measurement -History of Technology -Technology Management
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Camu Camu Mega-C 60 Veg Caps - Amazon Therapeutic Laborator
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Camu Camu Mega-C 60 Veg Caps - Amazon Therapeutic Laboratories Camu Camu Mega-C delivers 100% Camu Camu (Myrciaria dubia) dried berry extract in a convenient vegetarian capsule. This wild jungle berry is one of the highest recorded sources of vitamin C (more than oranges or lemons, and higher than acerola fruit). The fruit also delivers natural rutin and bioflavonoids.
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The first authoritative source on the subject, this referen
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The first authoritative source on the subject, this reference discusses the various levels of structure that influence the macroscopic physical properties of fat crystal networks. Fat Crystal Networks summarizes 50 years of structural research in the field, as well as a wealth of information on fat crystal networks pertinent to real-world challenges in industry. The book covers the physical chemistry of crystallization, emphasizing structure and mechanical properties as well as crystallization processes, and rheology of crystal networks in fats and lipid systems. Featuring a digital library containing 8000 high-resolution images of crystallized fats including cocoa butter, milkfat, milkfat fractions, and palm oil, the book contains state-of-the-art advancements gleaned from the editor's personal research in the field as well as contributions from several highly regarded colleagues. Fat Crystal Networks illustrates a wide range of analytical methodologies including pioneering studies on the use of 3-dimensional microscopy and the microanalysis of fat crystal networks and an introduction to the use of fractal analysis in the natural sciences. It also highlights recent methods to alter fat functionality through blending and physical manipulation, in-depth research available on the phase behavior of triacylglycerols, and coverage of formulation problems currently affecting the food industry.About the editor…Alejandro G. Marangoni is a Professor and Canada Research Chair at the University of Guelph, Ontario, Canada. He is the author, coauthor, or editor of numerous professional publications, including Physical Properties of Lipids and Soft Materials.
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Analyzing the behavior of complex networks is an important
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Analyzing the behavior of complex networks is an important element in the design of new man-made structures such as communication systems and biologically engineered molecules. Because any complex network can be represented by a graph, and therefore in turn by a matrix, graph theory has become a powerful tool in the investigation of network performance. This self-contained book provides a concise introduction to the theory of graph spectra and its applications to the study of complex networks. Covering a range of types of graphs and topics important to the analysis of complex systems, this guide provides the mathematical foundation needed to understand and apply spectral insight to real-world systems. In particular, the general properties of both the adjacency and Laplacian spectrum of graphs are derived and applied to complex networks. An ideal resource for researchers and students in communications networking as well as in physics and mathematics.
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Store Search search Title, ISBN and Author Measuring Dynami
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Store Search search Title, ISBN and Author Measuring Dynamic Network Interactions That Control Pituitary Gene Expression by Ignacio DeMarco Estimated delivery 3-12 business days Format Paperback Condition Brand New The combinatorial interactions of the homeodomain protein Pit-1 with transcription factors such as C/EBPalpha and with coregulatory proteins control the development of anterior pituitary cells. These cells fail to develop in individuals with mutations affecting the Pit-1 gene, result
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NF-kB is a critical signaling molecule in the immune system
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NF-kB is a critical signaling molecule in the immune system that regulates cell survival and cell death, lymphocyte responses, and inflammation. Acting as a transcription factor that can receive several inputs, it coordinates distinct gene expression programs in response to a wide variety of stimuli. Written and edited by experts in the field, this volume includes contributions covering the structure of NF-kB, its DNA-binding activity and specificity, the role of the inhibitor I-B, and canonical and alternative mechanisms of NF-kB activation. The contributors examine the physiological role of NF-kB in immune cells, as well as its functions in other tissues, such as the nervous system. They also discuss work indicating that NF-kB represents a critical link between inflammation and cancer. Including clinical perspectives on the use of NF-kB inhibitors in cancer therapy and a historical introduction by David Baltimore, in whose lab NF-kB was discovered, this volume is a vital reference for cell and molecular biologists, immunologists, and pathologists interested in regulation of cell function.
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The dysregulated activity of genetic regulatory networks c
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The dysregulated activity of genetic regulatory networks contributes to neoplastic transformation by promoting aberrant expression of genes involved in regulating cell homeostasis. Therefore, characterization of regulatory networks in human cancer cells is a critical objective in understanding the molecular mechanisms of cell transformation. Modern high throughput technologies are providing the first window into regulatory processes on the genome scale, foretelling the ability of computational inference algorithms to produce models of regulatory networks that will revolutionize our understanding and treatment of cancer by 1) describing how genomic alterations cause functional disruptions in the network regulating cell homeostasis, leading to aberrant cell growth and cancer, and 2) predicting therapeutic interventions, in which critical components of the network can be targeted to revert the cancer phenotype. This book will develop methods that advance the current state of the art in inferring genetic regulatory networks from high throughput data, with specific application to both gene expression and ChIP-on-chip data.
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"Molecular Gels: Materials with Self-Assembled Fibrillar Ne
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"Molecular Gels: Materials with Self-Assembled Fibrillar Networks" is a comprehensive treatise on gelators, especially low molecular-mass gelators and the properties of their gels. The structures and modes of formation of the self-assembled fibrillar networks (SAFINs) that immobilize the liquid components of the gels are discussed experimentally and theoretically. The spectroscopic, rheological, and structural features of the different classes of low molecular-mass gelators are also presented. Many examples of the application of the principal analytical techniques for investigation of molecular gels (including SANS, SAXS, WAXS, UV-vis absorption, fluorescence and CD spectroscopies, scanning electron, transmission electron and optical microscopies, and molecular modeling) are presented didactically and in-depth, as are several of the theories of the stages of aggregation of individual low molecular-mass gelator molecules leading to SAFINs. Several actual and potential applications of molecular gels in disparate fields (from silicate replication of nanostructures to art conservation) are described. Special emphasis is placed on perspectives for future developments. This book is an invaluable resource for researchers and practitioners either already researching self-assembly and soft matter or new to the area. Those who will find the book useful include chemists, engineers, spectroscopists, physicists, biologists, theoreticians, and materials scientists.
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The development of neural networks has now reached the stag
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The development of neural networks has now reached the stage where they are employed in a large variety of practical contexts. However, to date the majority of such implementations have been in software. While it is generally recognised that hardware implementations could, through performance advantages, greatly increase the use of neural networks, to date the relatively high cost of developing Application-Specific Integrated Circuits (ASICs) has meant that only a small number of hardware neurocomputers has gone beyond the research-prototype stage. The situation has now changed dramatically: with the appearance of large, dense, highly parallel FPGA circuits it has now become possible to envisage putting large-scale neural networks in hardware, to get high performance at low costs. This in turn makes it practical to develop hardware neural-computing devices for a wide range of applications, ranging from embedded devices in high-volume/low-cost consumer electronics to large-scale stand-alone neurocomputers. Not surprisingly, therefore, research in the area has recently rapidly increased, and even sharper growth can be expected in the next decade or so. Nevertheless, the many opportunities offered by FPGAs also come with many challenges, since most of the existing body of knowledge is based on ASICs (which are not as constrained as FPGAs). These challenges range from the choice of data representation, to the implementation of specialized functions, through to the realization of massively parallel neural networks; and accompanying these are important secondary issues, such as development tools and technology transfer. All these issues are currently being investigated by a large number of researchers, who start from different bases and proceed by different methods, in such a way that there is no systematic core knowledge to start from, evaluate alternatives, validate claims, and so forth. FPGA Implementations of Neural Networks aims to be a timely one that fill this gap in three ways: First, it will contain appropriate foundational material and therefore be appropriate for advanced students or researchers new to the field. Second, it will capture the state of the art, in both depth and breadth and therefore be useful researchers currently active in the field. Third, it will cover directions for future research, i.e. embryonic areas as well as more speculative ones.
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From the Earth's Lands & Sea Premium Quality USDA Organic S
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From the Earth's Lands & Sea Premium Quality USDA Organic Soy, Gluten and Dairy-Free Made with Organic Green Foods, High-ORAC Superfruits and Certified Amazonian Cocoa Certified Organic by ICO Don't be fooled by junk food disguised as health food. Greens
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Over the past few decades, mathematical modeling has been
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Over the past few decades, mathematical modeling has been extensively used to understand biological phenomena. From a cellular biology viewpoint, there has been much evidence that biochemical processes depend not only on the present state of the cell but also on previous reactions. The effects of these previous reactions are commonly due to a characteristic time delay between the signal and the response of the system. From a mathematical viewpoint, time delays bring complexity into the study of biological systems, but due to recent advances in the fields of differential delay equations and dynamical systems theory, these problems are now more tractable. The main purpose of this book is to provide a friendly mathematical approach to the analysis of differential delay equations. The analyses presented in this work should help modelers in the field of cell biology to further their understanding of some of the mathematical methods currently used to study gene networks with time delays.
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From the beginning of the OMICs biology era, science has be
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From the beginning of the OMICs biology era, science has been pursuing the reduction of the complex "genome-wide" assays in order to understand the essential biology that lies beneath it. In Protein Networks and Pathway Analysis, expert practitioners present a compilation of methods of functional data analysis, often referred to as "systems biology," and its applications in drug discovery, medicine and basic disease research. The volume is divided into three convenient sections, covering the elucidation of protein, compound and gene interactions, analytical tools, including networks, interactome and ontologies, and applications of functional analysis. As a volume in the highly successful Methods in Molecular Biology™ series, this work provides detailed descriptions and hands-on implementation advice. Authoritative and cutting-edge, Protein Networks and Pathway Analysis presents both "wet lab" experimental methods and computational tools in order to cover a broad spectrum of issues in this fascinating new field.
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Suma 1 oz Liquid - Amazon Therapeutic Laboratories Suma (Pf
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Suma 1 oz Liquid - Amazon Therapeutic Laboratories Suma (Pfaffia paniculata) is a long standing favorite botanical in South America. This product has been empirically selected for its effectiveness over many generations.
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Reflective Network Therapy describes a remarkably effective
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Reflective Network Therapy describes a remarkably effective school-based treatment method that harnesses small social networks for the good of seriously emotionally disturbed preschoolers or those with autism spectrum disorders. The book provides an in-depth explanation of the method — including the work of parents, peers, teachers, and mental health therapists. The RNT method has a substantial evidence base, with about the same number of treated children and a larger number of comparison and control cases as the published IQ results of the most widely used school based method. It has been used in many real life environments and is well-tested for feasibility, replicability, IQ effects, and children's global mental health results. The RNT method does not separate the child from peers by pairing him with an aide but is peer, teacher and parent inclusive. The cost-benefits and human benefits are extraordinary.
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Gene regulatory networks are the most complex, extensive co
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Gene regulatory networks are the most complex, extensive control systems found in nature. The interaction between biology and evolution has been the subject of great interest in recent years. The author, Eric Davidson, has been instrumental in elucidating this relationship. He is a world renowned scientist and a major contributor to the field of developmental biology. The Regulatory Genome beautifully explains the control of animal development in terms of structure/function relations of inherited regulatory DNA sequence, and the emergent properties of the gene regulatory networks composed of these sequences. New insights into the mechanisms of body plan evolution are derived from considerations of the consequences of change in developmental gene regulatory networks. Examples of crucial evidence underscore each major concept. The clear writing style explains regulatory causality without requiring a sophisticated background in descriptive developmental biology. This unique text supersedes anything currently available in the market. * The only book in the market that is solely devoted to the genomic regulatory code for animal development * Written at a conceptual level, including many novel synthetic concepts that ultimately simplify understanding * Presents a comprehensive treatment of molecular control elements that determine the function of genes * Provides a comparative treatment of development, based on principles rather than description of developmental processes * Considers the evolutionary processes in terms of the structural properties of gene regulatory networks * Includes 42 full-color descriptive figures and diagrams
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This book contains the latest development technologies in t
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This book contains the latest development technologies in the area of Power Systems. Deals with the deep-rooted linkages between existing and emerging concerns faced by distributed energy resources and their integration DESCRIPTION The conventional power system around the world is facing the problems of gradual depletion of fossil fuel resources, poor energy efficiency and environmental pollution. This has lead to the recent trend of generating power at distribution voltage level from renewable/non-conventional, small scale distributed energy resources (DERs) to culminate the advantages of improved energy efficiency, low emissions, better utilisation of eco-friendly energy sources, augmentation of low capital intensive generation, co-generation and tri-generation. However DERs suffer from the demerits of initial high cost, technical difficulties, absence of regulatory & marketing standards, lack of communication protocols, administrative & legal barriers, intermittent nature of generation etc. which are under extensive research worldwide. Technical development in the field of DERs is also resulting in the formation of MicroGrid (MG) & Active Distribution Networks (ADISNET). These are LV power supply networks comprising integrated DERs, designed to supply power to small community, operating either in synchronism with MV Regional Grid or as stand-alone systems. MG and ADISNET offer a potential solution for sustainable, energy-efficient power supply to cater for increasing load growth, supplying power to remote areas, generation of clean power and reduction in emission of greenhouse gases & particulates as per Kyoto protocol. CONTENTS DISTRIBUTED GENERATION AND MICROGRID CONCEPT Distributed Energy Sources Impacts of Microgrid Microgrid & Active Distribution Network Management System Protection Issues for Microgrids Power Electronic Interfaces SCADA & Active Distribution networks Impact of DG Integration on Power Quality and Reliability Microgrid Economics Market Participation of Microgrids - Appendices RELATED TITLES Distributed Generation 978-0-86341-958-4 (2009) Electricity Distribution Network Design 978-0-86341-309-4 (2003) The Institution of Engineering and Technology is one of the world's leading professional societies for the engineering and technology community. The IET publishes more than 100 new titles every year; a rich mix of books, journals and magazines with a back catalogue of more than 350 books in 18 different subject areas including: -Power & Energy -Renewable Energy -Radar, Sonar & Navigation -Electromagnetics -Electrical Measurement -History of Technology -Technology Management
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. AMAZON THERAPEUTIC LABORATORIES Cola de Caballo Liquid Ex
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. AMAZON THERAPEUTIC LABORATORIES Cola de Caballo Liquid Extract 1 oz Item#UI0058 UPC#838451003017 EXPIRATION DATE: At Least 2 Years Description coming soon. If you need information about this product, please contact us. Payment and Satisfaction Guarantee Shipping and Handling We use Paypal as our Payment Processor. If you don't have a Paypal account, you still may purchase directly with a major credit card. By using Paypal your transaction will be 100% risk-free. (Buyer Protection details ) We
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How can our societies be stabilized in a crisis? Why can w
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How can our societies be stabilized in a crisis? Why can we enjoy and understand Shakespeare? Why are fruitflies uniform? How do omnivorous eating habits aid our survival? What makes the Mona Lisa’s smile beautiful? How do women keep our social structures intact? – Could there possibly be a single answer to all these questions? This book shows that the statement: "weak links stabilize complex systems" provides the key to understanding each of these intriguing puzzles, and many more besides. The author, a recipient of several distinguished science communication prizes, explains weak or low probability interactions, and uses them as connecting threads in a vast variety of networks from proteins to ecosystems. This unique book and the ideas it develops will have a significant impact on diverse, seemingly unrelated fields of study.
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How can our societies be stabilized in a crisis? Why can w
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How can our societies be stabilized in a crisis? Why can we enjoy and understand Shakespeare? Why are fruitflies uniform? How do omnivorous eating habits aid our survival? What makes the Mona Lisa’s smile beautiful? How do women keep our social structures intact? – Could there possibly be a single answer to all these questions? This book shows that the statement: "weak links stabilize complex systems" provides the key to understanding each of these intriguing puzzles, and many more besides. The author, a recipient of several distinguished science communication prizes, explains weak or low probability interactions, and uses them as connecting threads in a vast variety of networks from proteins to ecosystems. This unique book and the ideas it develops will have a significant impact on diverse, seemingly unrelated fields of study.
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From the beginning of the OMICs biology era, science has be
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From the beginning of the OMICs biology era, science has been pursuing the reduction of the complex "genome-wide" assays in order to understand the essential biology that lies beneath it. In Protein Networks and Pathway Analysis, expert practitioners present a compilation of methods of functional data analysis, often referred to as "systems biology," and its applications in drug discovery, medicine and basic disease research. The volume is divided into three convenient sections, covering the elucidation of protein, compound and gene interactions, analytical tools, including networks, interactome and ontologies, and applications of functional analysis. As a volume in the highly successful Methods in Molecular Biology™ series, this work provides detailed descriptions and hands-on implementation advice. Authoritative and cutting-edge, Protein Networks and Pathway Analysis presents both "wet lab" experimental methods and computational tools in order to cover a broad spectrum of issues in this fascinating new field.
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The present book illustrates the theoretical aspects of sev
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The present book illustrates the theoretical aspects of several methodologies related to the possibility of i) enhancing the poor spatial information of the electroencephalographic (EEG) activity on the scalp and giving a measure of the electrical activity on the cortical surface. ii) estimating the directional influences between any given pair of channels in a multivariate dataset. iii) modeling the brain networks as graphs. The possible applications are discussed in three different experimental designs regarding i) the study of pathological conditions during a motor task, ii) the study of memory processes during a cognitive task iii) the study of the instantaneous dynamics throughout the evolution of a motor task in physiological conditions. The main outcome from all those studies indicates clearly that the performance of cognitive and motor tasks as well as the presence of neural diseases can affect the brain network topology. This evidence gives the power of reflecting cerebral "states" or "traits" to the mathematical indexes derived from the graph theory. In particular, the observed structural changes could critically depend on patterns of synchronization and desynchronization - i.e. the dynamic binding of neural assemblies - as also suggested by a wide range of previous electrophysiological studies. Moreover, the fact that these patterns occur at multiple frequencies support the evidence that brain functional networks contain multiple frequency channels along which information is transmitted. The graph theoretical approach represents an effective means to evaluate the functional connectivity patterns obtained from scalp EEG signals. The possibility to describe the complex brain networks sub-serving different functions in humans by means of "numbers" is a promising tool toward the generation of a better understanding of the brain functions. Table of Contents: Introduction / Brain Functional Connectivity / Graph Theory / High-Resolution EEG / Cortical Networks in Spinal Cord Injured Patients / Cortical Networks During a Lifelike Memory Task / Application to Time-varying Cortical Networks / Conclusions
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The questions of how a large population of neurons in the b
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The questions of how a large population of neurons in the brain functions, how synchronized firing of neurons is achieved, and what factors regulate how many and which neurons fire under different conditions form the central theme of this book. Using a combined experimental-theoretical approach unique in neuroscience, the authors present important new techniques for the physiological reconstruction of a large biological neuronal network. They begin by discussing experimental studies of the CA3 hippocampal region in vitro, focusing on single-cell and synaptic electrophysiology, particularly the effects a single neuron exerts on its neighbors. This is followed by a description of a computer model of the system, first for individual cells then for the entire detailed network, and the model is compared with experiments under a variety of conditions. The results shed significant light into the mechanisms of epilepsy, electroencephalograms, and biological oscillations and provide an excellent test case for theories of neural networks.
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. AMAZON THERAPEUTIC LABORATORIES Catuaba Certified Organic
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. AMAZON THERAPEUTIC LABORATORIES Catuaba Certified Organic 1 oz Item#UI0012 UPC#838451002461 EXPIRATION DATE: At Least 2 Years Payment and Satisfaction Guarantee Shipping and Handling We use Paypal as our Payment Processor. If you don't have a Paypal account, you still may purchase directly with a major credit card. By using Paypal your transaction will be 100% risk-free. (Buyer Protection details ) We have a Total Satisfaction Customer Guarantee. If you are not satisfied with your purchase, y
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Network-based representations have become pervasive in most
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Network-based representations have become pervasive in most fields in biology. Bacterial Molecular Networks: Methods and Protocols provides authoritative descriptions of various experimental and computational methods enabling the characterization and analysis of molecular interaction networks, with a focus on bacteria. Divided into three convenient sections, this volume provides extensive coverage of various experimental and in silico approaches aiming at the characterization of network components, addresses the presentation of computational approaches to analyze the topology of molecular networks, and further introduces a variety of methods and tools enabling scientists to generate qualitative or quantitative dynamical models of molecular processes in bacteria. Written in the highly successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and accessible, Bacterial Molecular Networks: Methods and Protocols is intended primarily for post-graduate students and researchers working in the field of experimental and computational microbiology and provides a combination of up-to-date reviews along with detailed protocols written by the developers of bioinformatics resources, such as databases and software tools.
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Gene regulatory networks play a vital role in organismal de
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Gene regulatory networks play a vital role in organismal development and function by controlling gene expression. With the availability of complete genome sequences, several novel experimental and computational approaches have recently been developed which promise to significantly enhance our ability to comprehensively characterize these regulatory networks by enabling the identification of respectively their genomic or regulatory state components, or the interactions between these two in unprecedented detail. Divided into five convenient sections, Gene Regulatory Networks: Methods and Protocols details how each of these approaches contributes to a more thorough understanding of the composition and function of gene regulatory networks, while providing a comprehensive protocol on how to implement them in the laboratory. Written in the highly successful Methods in Molecular Biology™ series format, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and accessible, Gene Regulatory Networks: Methods and Protocols aims to provide novices and experienced researchers alike with a comprehensive and timely toolkit to study gene regulatory networks from the point of data generation to processing, visualization, and modeling.
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