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Ion channels are membrane proteins that act as gated pathwa
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Ion channels are membrane proteins that act as gated pathways for the movement of ions across cell membranes. They play essential roles in the physiology of all cells. In recent years, an ever-increasing number of human and animal diseases have been found to result from defects in ion channel function. Most of these diseases arise from mutations in the genes encoding ion channel proteins, and they are now referred to as the channelopathies.Ion Channels and Disease provides an informative and up-to-date account of our present understanding of ion channels and the molecular basis of ion channel diseases. It includes a basic introduction to the relevant aspects of molecular biology and biophysics and a brief description of the principal methods used to study channelopathies. For each channel, the relationship between its molecular structure and its functional properties is discussed and ways in which genetic mutations produce the disease phenotype are considered. This book is intended for research workers and clinicians, as well as graduates and advanced undergraduates. The text is clear and lively and assumes little knowledge, yet it takes the reader to frontiers of what is currently known about this most exciting and medically important area of physiology. Key Features* Introduces the relevant aspects of molecular biology and biophysics* Describes the principal methods used to study channelopathies* Considers single classes of ion channels with summaries of the physiological role, subunit composition, molecular structure and chromosomal location, plus the relationship between channel structure and function* Looks at those diseases associated with defective channel structures and regulation, including mutations affecting channel function and to what extent this change in channel function can account for the clinical phenotype
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Despite being caused by one of the smallest animal viruses,
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Despite being caused by one of the smallest animal viruses, FMD is the most feared infection of domestic livestock; why is this so? There are three main reasons: 1) its facility for rapid spread is tremendous - it is often quoted as being the most infectious disease agent known; 2) its high morbidity - typically all members of a flock or herd of susceptible animals will become infected; 3) the loss of productivity associated with infection is about 25% - an unsupportable financial burden in modern farming practice. Its destructive potential has long been recognised and even in the 19th century considerable sums were invested in research into the nature and control of the disease. Because of this initial support and its continuation through the intervening years FMDV research has scored some notable goals in the advancement of fundamental virology. For example, it was the first animal disease to be shown to be caused by a virus, given the definition of a virus as an agent that could not be removed by filtration procedures recognised to eliminate bacteria. This early crucial observation has been followed by a string of milestone achievements in our understanding of the physical and biological nature of the virus and in methods for its control.This book summarises our current knowledge of FMD and FMDV, all of the authors who contributed to this volume are key players in their specialist areas within the FMDV story. Some were heavily involved with the diagnosis and control that the outbreaks of 2001 occasioned and the book benefits from including contributors with first hand experience of recent events.
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This comprehensive book examines how mineral nutrition affe
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This comprehensive book examines how mineral nutrition affects plant disease. Minerals improve the overall quality and health of plants. Knowing how each individual mineral affects a plant is beneficial for efficiency in production and sustaining the ecosystem. From a plant pathology perspective, Mineral Nutrition and Plant Disease brings the discussion of plant disease diagnosis and management to a new level. Mineral nutrients are important in production agriculture and horticulture because they can often be the first line of defense against plant diseases. It is an area of knowledge that can be misunderstood or overlooked in the study of diseases and their diagnosis. This reference succeeds in organizing what we know and explaining the interactions at work. Mineral Nutrition and Plant Disease is the first book to successfully combine two important plant science disciplines, nutrition and pathology, to provide current information on theoretical aspects of nutrition in disease physiology while contributing a wealth of basic practical information for obtaining immediate disease suppression with specific fertilizers.Special Features: Provides a holistic overview of how minerals are made available in soil and their basic function in plants Helps you understand the interacting affects of minerals on all types of diseases Abiotic as well as biotic Identifies mineral nutrient forms, physiological functions, and interactions with numerous diseases Provides valuable tables showing nutrient-disease interactions that facilitate the use of nutrients to manage diseases Tabulates extensive literature reviews with tables to help you perform quick searches for any host/disease systemThe book is peer-reviewed and multi-authored by scientists with expertise relating to each specific mineral element. A user-friendly benefit of this book is that each chapter focuses on one specific mineral element and explains the relationship between the nutrient and its affect on plant diseases. Each chapter describes the critical levels of each element involved in plant disease interactions, the effects of these elements on pathogens and plants, and the known mechanisms of how these elements suppress plant diseases. Benefits of specific mineral nutrients in each chapter recognize their interdependent interaction with each other and all aspects of the plant physiology, genetics, and the environment. These mineral nutrient chapters are preceded by two helpful chapters on the Chemistry of Plant Nutrients in Soil and The Physiological Role of Minerals in the Plant. The purpose of this important treatise is to outline the current knowledge of mineral nutrition and plant diseases. Readers will gain practical information for immediate disease management and understand the physiological role of each element in the plant and how it contributes to disease. Editors Datnoff, Elmer, and Huber, have done a commendable job in collaboration with their expert contributors. This book is pertinent to plant scientists worldwide including agronomists, plant physiologists, horticulturists, extension scientists, soil scientists, plant pathologists, and librarians who serve them. It will also be useful as a fundamental text to use for introductory courses in these disciplines.
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Now in its Twelfth Edition, Diseases of Poultry continues i
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Now in its Twelfth Edition, Diseases of Poultry continues its tradition of excellence as the definitive reference of poultry disease. Following the same user-friendly format, the book has been thoroughly updated to reflect the most current knowledge of avian pathology, including new coverage of genetic resistance to disease. Coverage is given to both common and uncommon diseases, and chapters are organized by disease type, including viral, bacterial, fungal, parasitic diseases as well as others, such as nutritional, developmental, metabolic, noninfectious diseases and toxins. Each disease section provides detailed coverage of history, etiology, pathobiology, diagnosis, and intervention strategies, as well as the economic and public health significance of each disease. With a host of international authors, Diseases of Poultry is a must-have resource for all veterinary pathologists, practitioners, agricultural managers and industry leaders involved in poultry health and production.
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The neck dissection has evolved over time by defining its a
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The neck dissection has evolved over time by defining its applications, tailoring it to the extent and location of regional disease, thereby using this information to expand or reduce the magnitude of the surgery itself. It has been labeled radical, functional, modified and selective depending on the sacrifice or preservation of certain muscles, nerves or vessels. The aim, however, has always been to encompass the lymph nodes at risk of harboring cancer. It has been described as elective (N0) or therapeutic (N+). It has been declared useful and appropriate for treating the neck in conjunction with cancers arising in the thyroid, the skin, the salivary glands, and the mucosa of the upper aerodigestive tract. In Neck Dissection: Management of Regional Disease in Head and Neck Cancer, Drs. Ferlito, Robbins and Silver have done a masterful job in compiling the collective wisdom of the best minds in the discipline; past and present. The information contained in the various chapters enlightens, inspires and challenges us. This book addresses the subject of node metastasis, its diagnosis, pathology, treatment and outcomes. Nothing is more important to the head and neck surgeon than to have a basic understanding of, and a "hands-on" familiarity with the various surgical options for treatment of cancer in the neck. The authors make it perfectly clear however, that it is still a work in progress. This progress comes with a price. Surgeons today are confronted with many choices or options regarding management of the neck in any particular case. No longer is only one type of dissection to be applied to all circumstances. In addition, many of these new choices are more tedious and technically challenging than the standard radical neck dissection. A poorly performed selective or modified neck dissection can result in an inadequate number or an inappropriate level of nodes removed, thus defeating its purpose.
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Everything you need to know about neuromuscular disease--in
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Everything you need to know about neuromuscular disease--in one concise, full-color volume "...this book will become an indispensable resource for clinicians involved in the diagnosis and management of patients with neuromuscular diseases, as well as for scientists working on the nature and pathogenesis of these disorders. It is a much-needed and welcome addition to the neurological literature and will rapidly gain acceptance as a standard work of reference."--Michael J. Aminoff, MD, DSc, FRCP, (from the foreword) Neuromuscular Disorders is comprehensive in scope, yet concise enough to serve as a valuable point-of-care guide for your day-to-day clinical practice. Grounded by numerous reference sources and enhanced by the experience of two seasoned clinicians, this text provides a pragmatic approach to the evaluation and management of neuromuscular disease. Here, in a single source, you'll get an insightful look at both nerve and muscle conditions, ranging from motor neuron diseases to neuropathies, neuromuscular junction disorders, and myopathies. The book opens with the clinical and laboratory approach to patients with neuromuscular disease, covering electrodiagnostic testing, nerve conduction studies, and muscle and nerve histopathology. With an emphasis on effective diagnosis and treatment, the substance of the text examines the full spectrum of specific neuromuscular diseases, giving you the “big picture” of the discipline in a way that no other text can match. FEATURES: Convenient coverage of both nerve, muscle and neuromuscular transmission disorders--both primary and secondary neuromuscular diseases Specific disease sections encompass the range of conditions likely to be encountered in clinical practice, including amyotrophic lateral sclerosis, myasthenia gravis, radiculopathies and plexopathies, mononeuropathies, various polyneuropathies, toxic myopathies, and dozens more The very latest diagnosis and treatment recommendations and protocols based on the most recent clinical literature and research Well-illustrated with EMGs, histopathology, and clinical photos
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This highly anticipated color diagnostic guidebook is a tho
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This highly anticipated color diagnostic guidebook is a thorough, authoritative, and practical reference for anyone who needs to diagnose and manage disease problems in brassica crops destined for vegetable markets, seeds, oil, and condiments. Fifty-nine international disease experts contributed to the coverage of more than a dozen brassica crops: Cabbage, Cauliflower, Broccoli, Brussels Sprouts, Kohlrabi, Greens, Asian Mustard Greens, Chinese Broccoli (Chinese Kale), Chinese Cabbage, Horseradish, Radish, Turnip, Rutabaga, Oilseed Rape (Canola, Rapeseed), and Culinary or Condiment Mustards. The book covers diseases caused by fungi, bacteria, mollicutes, viruses, and nematodes, as well as noninfectious damage to brassica crops such as herbicide injury, nutrient deficiencies, postharvest disorders, genetic abnormalities, and environmental damage. Plant pathologist-reviewed color photographs provide diagnostic guidance, and current approaches to disease management are provided at the end of each section. The disease sections are preceded by a helpful introduction to the taxonomy of the various Brassica species and the genetic relationships of this extraordinarily diverse group of plant types. Brassicas are widely cultivated throughout the world as leaf or root vegetable crops, for vegetable oil production, as fodder crops for livestock feeding, or as condiments and spices. They are increasingly important economic crops, and knowledge of their diseases is critical as is evidenced by the disease problems associated with the large increase in global production of both vegetable and oilseed brassicas. This compendium will be essential for extension scientists working in agriculture and horticulture and for other advisors, including individuals in regulatory agencies, as well as those in the private sector dealing with seed and fungicide retail and with disease scouting. The book is also useful for brassica crop growers, plant pathology and agriculture science teachers, students, research scientists, and plant breeders. This book comes in the new and improved APS PRESS Compendia Series format with color throughout and images included in the disease section.
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Compendium of Soybean Diseases, 4th Edition combines the fi
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Compendium of Soybean Diseases, 4th Edition combines the finest qualities of best-selling previous editions with updated and new sections, making it a thorough, authoritative and practical reference. Revisions to the 4th Edition include five new sections on different leaf spot diseases, an updated section on sudden death syndrome and many new color photographs. Soybean growers and crop advisors worldwide will find this color guidebook indispensable for preventing, diagnosing and controlling more than 100 diseases and disorders of soybean.Table of ContentsPreface; Introduction; Soybean Origin, Germ Plasm, Growth, Production, and Utilization; Soybean Diseases; Part 1: Infectious Diseases; Diseases Caused by Prokaryotes; Bacterial Diseases; Blight; Pustule; Tan Spot; Wildfire; Bacterial Wilts; Seedborne Bacteria; Other Bacteria; Crown Gall; Noneffective Biological Nitrogen Fixation; Diseases Associated with Mollicutes; Bud Proliferation; Machismo; Phyllody and Witches'-Broom; Update of Phytoplasmas in North America; Diseases Caused by Fungi; Fungal Diseases of Foliage, Upper Stems, Pods, and Seeds; Alternaria Leaf Spot and Pod Necrosis; Anthracnose; Aristostoma Leaf Spot and Yellowing; Black Leaf Blight; Brown Spot; Cercospora Blight, Leaf Spot, and Purple Seed Stain; Choanephora Leaf Blight; Downy Mildew; Drechslera Leaf Blight; Frogeye Leaf Spot; Leptosphaerulina Leaf Spot; Phyllosticta Leaf Spot; Powdery Mildew; Red Leaf Blotch; Rhizoctonia Foliar Blight; Rust; Scab; Stemphylium Leaf Spot; Target Spot; Fungal Diseases of Lower Stems and Roots; Brown Stem Rot; Charcoal Rot; Diaporthe-Phomopsis Complex; Phomopsis Seed Decay; Pod and Stem Blight; Stem Canker; Fusarium Diseases; Fusarium Blight or Wilt, Root Rot, and Pod and Collar Rot; Fusarium spp. Associated with Seeds; Sudden Death Syndrom; Phytophthora Rot; Pythium Damping-Off and Root Rot; Red Crown Rot; Rhizoctonia Root Rot; Sclerotinia Stem Rot; Sclerotium Blight; Thielaviopsis Root Rot; Other Fungi Associated with Root Rots; Other Fungi Reported in Soybean; Diseases Caused by Nematodes; Soybean Cyst; Lance; Lesion Reniform; Root Knot; Sting; Other Nematodes; Diseases Caused by Viruses; RNA; Alfamovirus; Alfalfa mosaic; Bromovirus; Cowpea Chlorotic Mottle; Carlavirus; Cowpea Mild Mottle; Carmovirus; Black Gram Mottle; Comoviruses Bean Pod Mottle; Cowpea Severe Mosaic; Other Comoviruses; Cucumoviruses; Soybean and Peanut Stunt; Furovirus; Soybean Yellow Vein; Ilarvirus; Tobacco Streak; Leteoviruses; Indonesian Soybean Dwarf; Soybean Dwarf; Nepoviruses; Soybean Severe Stunt; Tobacco Ringspot; Other Nepoviruses Potyviruses; Bean Yellow Mosaic; Peanut Mottle; Soybean Mosaic; Tobamovirus; Tobacco Mosaic; DNA; Begomoviruses; Mungbean Yellow Mosaic; Soybean African Dwarf; Soybean; Crinkle Leaf; Caulimovirus; Soybean Chlorotic Mottle; Genome Unknown; Soybean Mild Mosaic; Other Virus Diseases; Seed and Postharvest Pathology; Detection of Seedborne Pathogens; Seedborne Bacteria; Seedborne Field Fungi; Yeast Spot; Other Seedborne Field Fungi; Storage Fungi;Part 2: Noninfectious or Stress Disorders Crusting and Compaction; Frost; Hail; Heat Canker; Lightning; Sunburn; Water Stress; Mineral Deficiencies and Toxicities; Herbicide Damage; Insecticide Damage; Air Pollutants;Part 3: Soybean Disease Management Strategies Introduction; Preventive Measures; Preemptive Measures; Remedial Measures; Appendix; Index
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Recent interest in new diseases, such as HIV/AIDS and Ebola
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Recent interest in new diseases, such as HIV/AIDS and Ebola, and the resurgence of older diseases like tuberculosis has fostered questions about the history of human infectious diseases. How did they evolve? Where did they originate? What natural factors have stalled the progression of diseases or made them possible? How does a microorganism become a pathogen? How have infectious diseases changed through time? What can we do to control their occurrence? Ethne Barnes offers answers to these questions, using information from history and medicine as well as from anthropology. She focuses on changes in the patterns of human behavior through cultural evolution and how they have affected the development of human diseases. Writing in a clear, lively style, Barnes offers general overviews of every variety of disease and their carriers, from insects and worms through rodent vectors to household pets and farm animals. She devotes whole chapters to major infectious diseases such as leprosy, syphilis, smallpox, and influenza. Other chapters concentrate on categories of diseases ("gut bugs," for example, including cholera, typhus, and salmonella). The final chapters cover diseases that have made headlines in recent years, among them mad cow disease, West Nile virus, and Lyme disease. In the tradition of Berton Roueché, Hans Zinsser, and Sherwin Nuland, Ethne Barnes answers questions you never knew you had about the germs that have threatened us throughout human history.
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Whether they are called peppers, chiles, paprika, or ajis,
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Whether they are called peppers, chiles, paprika, or ajis, plants in the genus Capsicum, are among the most important spice and vegetable commodities worldwide because they are used in so many different types of food. Like other crops, peppers are afflicted with diseases, disorders, and pests that can reduce fruit quality and yield.The Compendium of Pepper Diseases provides a comprehensive presentation of the important pepper diseases of the world. With the help of 122 color photographs and thorough descriptions of pathogens, this valuable reference enables readers to easily identify diseases on the basis of symptoms and formulate field and laboratory diagnoses of diseases caused by bacteria, fungi, viruses, parasitic angiosperms, and nematodes.Readers will also learn about the geographical distribution and impact of each disease, control measures, and epidemiological aspects of diseases as well as gain knowledge on plant health problems associated with arthropods, nutritional deficiencies, herbicide injuries, and other abiotic causes. This compendium also includes sections discussing the botany of pepper, current production practices, and postharvest damage to pepper fruit.Edited and authored by 39 professionals with international expertise in pepper pathology in several unique production areas and in diverse areas of pathogen expertise, the Compendium of Pepper Diseases will prove invaluable to growers, extension agents, county agents, crop production specialists, researchers, plant pathologists, horticulturists, agronomists, agribusiness professionals, educators, students and anyone interested in the diagnosis or management of diseases of pepper crops throughout the world.
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This textbook is specifically designed for upper-division u
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This textbook is specifically designed for upper-division undergraduate or graduate students in life science or pre-medical majors including dentistry or pharmacology, who are required to take a biochemistry or medical biochemistry course, but who are not necessarily biochemistry majors. The book adopts a unique approach to the topic compared with other biochemistry textbooks currently available, in that each biochemical subject is introduced by a human disease relating the biochemical principles to be developed in that chapter. The goal is to make biochemistry more meaningful to the student who is not normally shown the connection between biochemistry and medicine. * Includes an abundance of figures* Emphasizes human biochemistry* Introduces each chapter with a relevant disease or clinical relationship
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The authority of Harrison's in a handy, full-color paperbac
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The authority of Harrison's in a handy, full-color paperback devoted exclusively to Infectious Diseases 5 STAR DOODY'S REVIEW! "This book provides all the latest knowledge in the field and is supported by the scientific rigor and reliability that have defined Harrison's....This book is an essential compact clinical companion for students and clinicians alike....This book is complete, easy to navigate, and remarkably up to date. As the parent text does, this book devotes significant attention to the importance of obtaining a history and conducting a physical examination, the basic foundation of all medicine. It blends the other myriad aspects of infectious diseases and offers eminently readable and current management recommendations. Indeed, it should be regarded as an authoritative source of current information on infectious diseases."--Doody's Review Service Featuring the chapters on Infectious Diseases that appear in the landmark Harrison's Principles of Internal Medicine, 17e, this compact clinical companion delivers all the latest knowledge in the field, backed by the scientific rigor and reliability that have defined Harrison's. You'll find coverage that reflects the expertise of renowned editors and contributors -- presented in a carry-anywhere format that makes it ideal for the classroom, the wards, or the point of care. With its ease of use, indispensable diagnosis-speeding guidelines, and acclaimed state-of-the-art strategies, Harrison's Infectious Diseases is a must for students and clinicians alike. Harrison's Infectious Diseases delivers: Current, complete coverage of essential infectious diseases topics, including infections in organ systems, bacterial infections, viral infections, prion diseases, fungal and algal infections, and protozoal and helminthic infections 100+ high-yield Q&A drawn from Harrison's Principles of Internal Medicine Self-Assessment and Board Review, 17e 6 complete chapters in print format from the Harrison's DVD 127 chapters written by experts who have made significant contributions to knowledge in their fields References and other material that have been updated since the publication of HPIM 17e Integration of pathophysiology with clinical management topics in each of the disease-oriented chapters Helpful appendix of laboratory values of clinical importance The Harrison’s specialty series is written by the same world-renowned author team who brought you Harrison’s Principles of Internal Medicine, 17e: Anthony S. Fauci, MD; Eugene Braunwald, MD; Dennis L. Kasper, MD; Stephen L. Hauser, MD; Dan L. Longo, MD; J. Larry Jameson, MD, PhD; Joseph Loscalzo, MD, PhD
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Plant disease epidemics, caused by established and invasive
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Plant disease epidemics, caused by established and invasive pathogen species, continue to impact a world increasingly concerned with the quantity and quality of its primary food supply. The Study of Plant Disease Epidemics is a comprehensive manual that introduces readers to the essential principles and concepts of plant disease epidemiology. This useful reference and textbook provides a detailed exposition on how to describe, compare, analyze, and predict epidemics of plant disease for the ultimate purposes of developing and testing control strategies and tactics. The authors have synthesized the research advances from the last four decades, with a special emphasis on research done in the last 15 years, to produce a useful framework for: - Measuring plant disease - Quantifying and modeling disease development in time and space - Quantifying patterns of disease and sampling for disease in populations - Determining decision thresholds for control interventions - Characterizing the relationship between disease development and crop loss This new reference introduces a coherent theory of disease development in plant host populations over time and space, coupled with detailed explanations of the components of diseases in crops and forests. This theory demonstrates how different levels of mathematical complexity can lead to unifying principles of disease invasion, persistence, and rates of temporal increase and disease expansion from foci. In addition, the book shows how disease control strategies are intricately related to fundamental population-biology parameters. The information on modeling and statistical analysis provides the needed tools and procedures for researchers to help them properly measure and analyze collected epidemiological data and maximize its value. The methods and principles described throughout the book explain how to translate this valuable data and utilize it to make informed disease management decisions.The Study of Plant Disease Epidemics is the highly anticipated original work by three of the leading plant disease epidemiologists of the last quarter century. This manual is an essential tool intended for graduate students, researchers, and teachers of plant pathology, as well as crop consultants and those in disease management positions. It will be an excellent teaching tool for courses in Plant Disease Epidemiology, Plant Disease Management, Invasive Species Risk Assessment, and Plant Pathogen Ecology.
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This monograph presents the knowledge of tongue examination
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This monograph presents the knowledge of tongue examination of warm diseases of Traditional Chinese Medicine (TCM) with pictures and accompanying essays. There are more than 150 pictures and essays in this book, which gives a brief summary of characteristics, indications and treatment principles of the tongues appearance in warm diseases. Based on the national textbook, Seasonal Febrile Disease of TCMWn Bìng Xué, this book is recommended for educational purposes. As an important diagnostic method in epidemic febrile disease, tongue examination has been highly valued by doctors through the ages. Today the skillful and correct mastery of it is a basic requirement for modern physicians in clinical practice. All the pictures of the tongue were taken from patients suffering from warm disease including acute epidemic disease, acute infectious disease, and burns. Pictures in this book cover lips, tooth, and even the face, including an oily and dirty face, flushed face, gum bleeding, mouth corner bleeding, dry lip, and lip sores, in order to clarify the relationships between tongue and other manifestations. The tongue manifestations in this book are classified and edited according to the national textbook, Seasonal Febrile Disease of TCM (Wn Bìng Xué, ), and the systematic and broad scope of the content is beneficial for teaching. All the pictures in this book come from clinics. Some pictures, like those of tongue sores, linguofacial blood-streak, and sublingual varicosity, are rare and unique and can be used to supplement textbooks. This book is mainly consists of pictures of the tongue, with brief introductions covering the characteristics, indications and treatment principles of tongue manifestations in warm disease. It is a good clinical reference for doctors. Finally, any corrections and/or suggestions concerning its content would be appreciated.
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In a vicious cycle, poor nutritional health leads to acute
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In a vicious cycle, poor nutritional health leads to acute and chronic disease, and disease states are catastrophic to nutritional health. The magnitude of nutritional depletion from any cause depends to a large extent on the nutritional reserves an individual has accumulated over time. In our increasingly older population, nutritional reserves are marginal and the magnitude of the effect on nutritional health is amplified. Strategies to improve nutritional health in older individuals require a unique approach and sensitivity to the individual’s needs. Drawing from a group of outstanding experts in the field, Geriatric Nutrition is a state-of-the-art review of current nutritional thinking. Beginning with an overview of nutrition in older persons, the book addresses nutrition epidemiology, obesity, immunity, as well as molecular theories of aging. A detailed scientific review of nutritional requirements follows with chapters on energy balance, water metabolism, vitamin disorders, and trace elements. Techniques for the clinical assessment of nutrition in older adults include comparisons between US and European Union strategies and standards. The book includes a revealing section on the management of undernutrition in nursing homes and assisted living environments. It offers prescriptions for enteral and parenteral nutrition, as well as protein energy undernutrition. A significant portion of the book covers nutrition recommendations in specific disease states, including psychological issues such as dementia and depression, cancer, diabetes, anemia, and fracture risk. The book also considers multicultural and ethical issues relevant to the sensitive treatment of older individuals. Exploring exciting new ideas in normal, pathological, and optimal nutrition, Geriatric Nutrition ties basic research with clinical practiceto further the understanding of nutrition in older persons.
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Staphylococci remain the most important cause of hospital-a
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Staphylococci remain the most important cause of hospital-acquired infections in the U.S. and MRSA has become the most common cause of skin and soft tissue infection in many parts of the world.There is now a much greater understanding of the physiology and evolution of the staphylococci and this new edition reflects the rapid advancements in knowledge about this pathogen and provides a comprehensive review from both clinical and basic science perspectives.The first section addresses the basic biology of the staphylococci, their molecular genetics, host defenses and host evasion, virulence determinants, mechanisms of antibiotic resistance, and laboratory techniques. The second section deals with epidemiology, and the third section provides an overview of the varied clinical manifestations of human staphylococcal infections. The fourth section covers prevention and treatment of these often life-threatening infections.Written by experts from around the globe, this book is essential reading for all clinicians and basic scientists studying the staphylococci.
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The fully revised second edition of the Encyclopedia of Hea
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The fully revised second edition of the Encyclopedia of Heart Diseases is an ideal resource for practicing clinicians and researchers. Available in print, online, and with dual access, it is a clear and comprehensive aggregation of the most crucial information and essential data on cardiovascular diseases and therapeutics. Comprised of over 95 entries with regular online updates, the Encyclopedia of Heart Diseases is fully referenced, and major points of interests are hyperlinked to complementary sections. Each entry is logically and superbly written, providing accurate core knowledge of pathogenesis, pathophysiology, clinical features, diagnostic techniques, and management strategies. Specific detail is paid to technological advances in imaging and diagnostics. Therapy focused entries give powerful insights into not only prescribing drug regimens, but also into the controversies surrounding their use. This major reference work is invaluable for all those involved in the care of cardiovascular patients. From the front-line practitioner to the basic science researcher to the student in training, the Encyclopedia of Heart Diseases offers an astute authoritative guide to navigating an immense body of fascinating information. From the trainee to the internist and cardiologist, all will find it useful. It is an essential resource for medical libraries and academic institutions worldwide. From the Foreword: So, what would we want from an encyclopedia on heart disease? Ideally, a book would be comprehensive, yet concise, and be practically oriented, and explain pathophysiology and treatment. In addition, it should be accessible online so that it can be accessed at the bedside or anywhere. Dr. Khan has written exactly such a book. Encyclopedia of Heart Diseases is comprehensive, yet concise, and very practically oriented. Importantly, it takes a step-by-step approach, walking the reader through a thorough pathophysiology of conditions, their evaluation and treatment. For therapies, he provides the mechanism of the drug, its doses, side effects and clinical efficacy. ...A terrific online resource with all the information you need! - Christopher P. Cannon, MD, TIMI Study Group, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
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Disease-related malnutrition is a global public health prob
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Disease-related malnutrition is a global public health problem. The consequences of disease-related malnutrition are numerous, and include shorter survival rates, lower functional capacity,longer hospital stays, greater complication rates, and higher prescription rates.Nutritional support, in the form of oral nutritional supplements or tube feeding, has proven to lead to an improvement in patient outcome. This book is unique in that it draws together the results of numerous different studies that demonstrate the benefits of nutritional support and provides an evidence base for it. It also discusses the causes, consequences, and prevalence of disease-related malnutrition, and provides insights into the best possible use of enteral nutritional support.
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Liberally illustrated throughout with over 400 photographs
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Liberally illustrated throughout with over 400 photographs (300 in full colour), this reference provides a practical and clinically oriented approach to the diagnosis and management of macular disorders. It covers not only diseases that primarily affect the macula, such as age-related macular degeneration, but also those that might have an indirect but never-the-less significant effect on macular function, such as vascular and inflammatory diseases. Many diseases in this book are illustrated with brief case studies, to help bring them to life and facilitate learning.With over 400 top quality clinical pictures, this book enables easy visual recognition of macular diseases. Covers all disorders associated with macular degeneration not only age-related macular degeneration. Includes case histories which is an invaluable and unique diagnostic tool that facilitates learning. Each chapter covers the most common disease first, followed by less common conditions which guides the reader towards an accurate diagnosis. Written as a quick and easy reference.
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Paratuberculosis, also referred to as Johne's disease, affe
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Paratuberculosis, also referred to as Johne's disease, affects cattle, goats, sheep, buffalo, deer and other ruminants. It is common worldwide and responsible for significant economic losses in the dairy industry. Recent advances in detection, vaccination and microbial genetics make this a timely book that examines the epidemiology of paratuberculosis, the organism that causes the disease, and practical aspects of its diagnosis and control. It also addresses the link between paratuberculosis in the food chain and human health implications, including Crohn's disease. This authoritative text is an essential resource for large animal veterinarians, livestock industry personnel and those involved in the dairy and meat industries, as well as microbiologists, researchers and students in these fields.
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The only source on the subject to offer both an overview an
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The only source on the subject to offer both an overview and a disease-based approach, this reference text spans the wide array of technical, methodological, regulatory, and ethical issues related to pharmacogenetics and stresses the impact of pharmacogenetic data on patient care and management. Providing expertly selected references, tables, and figures in each chapter, this guide details the relevance of pharmacogenetic applications to disease based specialities including sections on pharmacogenetics of cardiovascular, respiratory, central nervous system, infectious, gastroenterological, oncologic, hematologic, metabolic, and rheumatologic disorders.
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Ageing has become a great problem for many countries. Due t
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Ageing has become a great problem for many countries. Due to world-wide life prolongation, the number of people over 60 years old has grown rapidly into a ten percent piece of the world population. The growing age of the world population raises many social, economical, and medical problems. The proportion of people in the economically active age groups to those who are over 65 is constantly decreasing. A major consequence of the increasing numbers of individuals in advanced age groups is increasing numbers of patients suffering from age-related diseases. The aim of this book is to present the basic data on human ageing as well as on age-related diseases.
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Learn about the benefits of transitioning to a healthier di
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Learn about the benefits of transitioning to a healthier diet in order to fight diseases such as fibromyalgia, lupus, chronic fatigue, migraine headaches, and other inflammatory based conditions; or learn how to eat well just to stay healthy in general. This book is a guide to fighting inflammatory diseases, fibromyalgia, chronic fatigue syndrome, polymyalgia, lupus and other autoimmune based disorders. In this book Dr. Clairborne explores what foods cause inflammation, why preparation method is so important, and how to use the anti-inflammatory diet to change the course of any inflammatory disease. She gives a summary of healthy detoxification and supplements that she considers essential to cleansing and to every day health and well-being. She then takes the reader on a journey through the processes of healthy shopping, meal planning, healthy cooking basics, and quick preparation for the busy person. Finally she will share simple, fun, and practical tips that the reader can incorporate into an efficient daily practice through meal planning. By the end of this book the reader will understand the body's inflammatory process, know how to use food to reverse this, and realize that it doesn't have to be overwhelming, stressful, or expensive, and that it can in fact be quite simple, tasty, cost effective and even fun.
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In Crime, Punishment and Disease, Antony Flew makes clear b
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In Crime, Punishment and Disease, Antony Flew makes clear both the meaning and the implications carried by the application of the expression "mental disease." He aims to discourage its use in conditions that provide the victims of such diseases with an excuse for failing to perform what would have been their imperative duties had they enjoyed good mental health. Flew attacks the gross over-extensions of the notion of mental disease on both sides of the Atlantic. He defends human dignity and responsibility against the suggestion that we are all, or most of us, "sick, sick, sick." In particular, he challenges the paternalist pretensions of people who claim a right to control and manipulate others because they are allegedly sick, and consequently not responsible for what they do. In a typical ordinary disease, Flew notes, it is the patient who complains of the disease rather than someone else who complains about the patient. But those who claim that some crime or all crime is symptomatic of mental disease and those who identify disorders such as attention/deficit/hyperactivity disorder (ADHD) as conditions requiring psychiatric attention are taking the disfavored behavior rather than the distress of their patients as the warrant for supposedly medical interventions. They should instead first consider how what they propose to call mental disease does, and does not, resemble syphilis, measles, and other communicable diseases. Flew sees his work as complementary to Thomas Szasz's. He applies a philosophical perspective to problems Szasz discusses as a psychiatrist. This work will be of particular interest to students of philosophy and politics, in that it relates modern discussion of mental illness to the Plato of The Republic. Flew also takes note in this context of Samuel Butler's Erewhon. This work will be of direct relevance to criminologists, as well as those interested in social welfare, philosophy of education, and new developments in psychiatry.
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In the 1850s, "Drapetomania" was the medical term for a dis
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In the 1850s, "Drapetomania" was the medical term for a disease found among black slaves in the United States. The main symptom was a strange desire to run away from their masters. In earlier centuries gout was understood as a metabolic disease of the affluent, so much so that it became a badge of uppercrust honor -- and a medical excuse to avoid hard work. Today, is there such a thing as mental illness, or is mental illness just a myth? Is Alzheimer's really a disease? What is menopause -- a biological or a social construction?Historically one can see that health, disease, and illness are concepts that have been ever fluid. Modern science, sociology, philosophy, even society -- among other factors -- constantly have these issues under microscopes, learning more, defining and redefining ever more exactly. Yet often that scrutiny, instead of leading toward hard answers, only leads to more questions. Health, Disease, and Illness brings together a sterling list of classic and contemporary thinkers to examine the history, state, and future of ever-changing "concepts" in medicine. Divided into four parts -- Historical Discussions; Characterizing Health, Disease, and Illness; Clinical Applications of Health and Disease; and Normalcy, Genetic Disease, and Enhancement: The Future of the Concepts of Health and Disease -- the reader can see the evolutionary arc of medical concepts from the Greek physician Galen of Pergamum (ca. 150 ce) who proposed that "the best doctor is also a philosopher," to contemporary discussions of the genome and morality. The editors have recognized a crucial need for a deeper integration of medicine and philosophy with each other, particularly in an age of dynamically changing medical science -- and what it means, medically, philosophically, to be human.
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Would you believe that something could:Extend your youth by
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Would you believe that something could:Extend your youth by more than ten years?Boost your immune system in two weeks' time?Help prevent heart disease, Alzheimer's, Parkinson's, diabetes, and cataracts?Cut your recovery time from jet lag in half?Offer not just cancer prevention but a key to a cure?All in a widely available non-prescription capsule? It's true--and it's called melatonin. This remarkable book represents a major breakthrough in human health and life extension studies. It reveals cutting-edge research on melatonin--a natural hormone produced deep within the brain--that is revolutionizing our understanding of life. Melatonin helps determine how fast we age, how effectively we fight off disease and toxins, and how well we sleep.Melatonin is the most comprehensive, up-to-date, and authoritative book available about this amazing substance. Dr. Russel J. Reiter is one of the world's leading experts in the field. During more than thirty years of pioneering research, he has uncovered many of melatonin's unique properties-- including its role as the most powerful antioxidant in the body. In this book he reveals what he and other scientists around the world have only recently discovered about melatonin's remarkable potential to:Increase immune response dramaticallyGreatly improve existing treatments for cancer and AIDSLower cholesterol and blood pressurePut you to sleep as effectively as a prescription drug--without side effectsImprove mood and reduce symptoms of PMSPrevent the free radical damage that underlies agingNeutralize the dangerous side effects of mammograms, X-rays, and surgeryIn Melatonin, Reiter offers a complete, three-phase program to help you take advantage of this new information right now. First, he helps you pinpointthe habits, hidden environmental hazards, and common medications that may be diminishing your natural supply of melatonin. Next, he explains how you cannaturally stimulate your production of this life-giving hormone. Finally, he provides a complete guide to melatonin supplements, including safe and effective doses, the best kind to buy, and when and how to take them.With all the suspense of a medical detective story, Melatonin reveals clue by tantalizing clue all of the amazing properties of this "hidden" wonder hormone, much the way they presented themselves to Dr. Reiter and his colleagues. The result is a book that only an insider could write--a book as exciting to read as it is vital to your health and the health of those you love.
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Ion channels are membrane proteins that act as gated pathwa
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Ion channels are membrane proteins that act as gated pathways for the movement of ions across cell membranes. They play essential roles in the physiology of all cells. In recent years, an ever-increasing number of human and animal diseases have been found to result from defects in ion channel function. Most of these diseases arise from mutations in the genes encoding ion channel proteins, and they are now referred to as the channelopathies.Ion Channels and Disease provides an informative and up-to-date account of our present understanding of ion channels and the molecular basis of ion channel diseases. It includes a basic introduction to the relevant aspects of molecular biology and biophysics and a brief description of the principal methods used to study channelopathies. For each channel, the relationship between its molecular structure and its functional properties is discussed and ways in which genetic mutations produce the disease phenotype are considered. This book is intended for research workers and clinicians, as well as graduates and advanced undergraduates. The text is clear and lively and assumes little knowledge, yet it takes the reader to frontiers of what is currently known about this most exciting and medically important area of physiology. Key Features* Introduces the relevant aspects of molecular biology and biophysics* Describes the principal methods used to study channelopathies* Considers single classes of ion channels with summaries of the physiological role, subunit composition, molecular structure and chromosomal location, plus the relationship between channel structure and function* Looks at those diseases associated with defective channel structures and regulation, including mutations affecting channel function and to what extent this change in channel function can account for the clinical phenotype
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Presenting both the concerns and problems of beer consumpti
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Presenting both the concerns and problems of beer consumption as well as the emerging evidence of benefit, Handbook of Beer Health and Disease Prevention offers a balanced view of today's findings and the potential of tomorrow's research. From a beverage of warriors to a cheap and affordable commodity, beer has been a part of our consumption for nearly 8000 years. Like most alcoholic drinks it has been prone to abuse and in some counties the per capita consumption of beer has led to considerable health risks. However, just as wine in moderation has been proposed to promote health, research is showing that beer -- and the ingredients in beer -- can have similar impact on improving health, and in some instances preventing disease. For example, some cancers like bladder cancers and the incidence of cardiovascular disease are reported to be lower in moderate beer drinkers. Furthermore there is a considerable body of emerging evidence to show that the anti-oxidant capacity of beers is high. It has been argued by some that the total antioxidants ingested in some beer drinkers equates that consumed by red wine drinkers. The key to this, of course, is understanding and this volume presents a collection of the most current writings on the subject of beer and it's potential in health. Winner of the 2009 Best Drinks and Health Book in the World - Gourmand World Cookbook Awards *The most comprehensive coverage of the broad range of topics related to the role of beer and beer ingredients in health *Addresses the impact of beer and beer ingredients on cancers, cardiovascular disease, anti-oxidant benefits, and other health related concerns Presents a holistic view from beer brewing to the isolation of beer-related compounds. *Appropriate for scientists and researchers from a variety of fields and industries from beer production to health-care professionals *Consistent organization of each chapter provides easy-access to key points and summaries *Self-contained chapters written by subject matter experts
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"This is essential reading for everyone who would like to u
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"This is essential reading for everyone who would like to update their knowledge of the pulmonary epithelium. It offers a comparison between laboratory animal models and human lungs, highlighting the differences and the similarities between the two, which will be particularly useful to researchers." –Doody's, April 2009The past two decades have seen extraordinary advances in our understanding of the role of the pulmonary epithelium in airway health and disease. Our understanding of epithelial biology has expanded exponentially in the past decade.This book provides a unique comprehensive description of the structure of the epithelium, its damage by various agents and the mechanism of epithelial repair. In addition, it's detailed coverage includes not only the multiple ways in which the epithelium contributes to host defence, but also the nature and functional consequences of the interactions of inhaled pathogens, including viruses, bacteria, allergens and pollutants. the role of the epithelium in regulating airway inflammation and structure is also discussed, as is the role of the epithelium as a target for inhaled medications and as a route for novel drug delivery.Containing chapters on multiple aspects of epithelial function in health and disease, each one is written by a leader in the field. This is essential reading for pulmonary researchers and physicians requiring detailed advanced understanding of the epithelium as well as those working in allergy, biomedical and pharmaceutical research.
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The role of epigenetic mechanisms in autoimmune disease is
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The role of epigenetic mechanisms in autoimmune disease is only now starting to become clear. Understanding these mechanisms, their effect on cellular function and the role of environmental factors is vital to determining how to manage these often debilitating and fatal diseases.Drawing on the research of leading experts, this book provides a valuable insight into this important new area of autoimmunity research and a clear, up-to-date view on the major advances in the field.Specific coverage includes:How highly developed epigenetic mechanisms are involved in several aspects of normal immune regulation, in addition to maintaining immune tolerance to self-determinants.Specific epigenetic aspects of human autoimmune diseases, including multiple sclerosis, systemic lupus erythematosus, rheumatoid arthritis, systemic sclerosis, autoimmune diabetes, thyroid autoimmunity, inflammatory bowel disease and autoimmune hepatitis.How understanding epigenetic mechanisms can lead to therapeutic strategies based on manipulation of this previously unexploited facet of immune regulation.Discussion of the novel approaches that are being investigated to prevent or treat autoimmune diseases.This book is an essential resource for those actively involved in the field. It is also of interest to basic researchers interested in understanding the origin of autoimmunity and clinical specialists interested in gaining in-depth understanding of the pathogenesis of autoimmune diseases and their treatment.
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