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Trifexis for Dogs 40.1-60 lbs, 6 Chewable Tablets (Blue) T ... Read more

Trifexis for Dogs 40.1-60 lbs, 6 Chewable Tablets (Blue) Trifexis for Dogs 40.1-60 lbs, 6 Chewable Tablets (Blue) is an oral heartworm treatment and flea prevention medication for dogs. Trifexis pet meds kill fleas, prevent further flea infestations, and treat and control adult hookworm, roundworm, and whipworm. TRIFEXIS™ Elanco (spinosad + milbemycin oxime) Chewable Tablets Caution: Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian. Description: TRIFEXIS (spinosad and milbemycin oxime) is available in five sizes for oral administration to dogs and puppies according to their weight. Each chewable flavored tablet is formulated to provide a minimum spinosad dose of 13.5 mg/lb (30 mg/kg) and a minimum milbemycin oxime dose of 0.2 mg/lb (0.5 mg/kg). Spinosad is a member of the spinosyns class of insecticides, which are non-antibacterial tetracyclic macrolides. Spinosad contains two major factors, spinosyn A and spinosyn D, derived from the naturally occurring bacterium, Saccharopolyspora spinosa . Spinosyn A and spinosyn D have the chemical compositions C 41 H 65 NO 10 and C 42 H 67 NO 10 , respectively. Milbemycin oxime is a macrocyclic lactone anthelmintic, containing two major factors, A 3 and A 4 of milbemycin oxime. The approximate ratio of A 3 :A 4 is 20:80. Milbemycin A 4 5-oxime has the chemical composition of C 32 H 45 NO 7 and milbemycin A 3 5-oxime has the chemical composition of C 31 H 43 NO 7 . Indications: TRIFEXIS is indicated for the prevention of heartworm disease (Dirofilaria immitis) . TRIFEXIS kills fleas and is indicated for the prevention and treatment of flea infestations (Ctenocephalides felis) , and the treatment and control of adult hookworm (Ancylostoma caninum) , adult roundworm (Toxocara canis and Toxascaris leonina) and adult whipworm (Trichuris vulpis) infections in dogs and puppies 8 weeks of age or older and 5 pounds of body weight or greater. Dosage and Administration: TRIFEXIS is given orally, once a month at the minimum dosage of 13.5 mg/lb (30 mg/kg) spinosad and 0.2 mg/lb (0.5 mg/kg) milbemycin oxime body weight. For heartworm prevention, give once monthly for at least 3 months after exposure to mosquitoes (see EFFECTIVENESS ). Dosage Schedule: Body Weight Spinosad Per Tablet (mg) Milbemycin oxime Per Tablet (mg) Tablets Administered 5 to 10 lbs 140 2.3 One 10.1 to 20 lbs 270 4.5 One 20.1 to 40 lbs 560 9.3 One 40.1 to 60 lbs 810 13.5 One 60.1 to 120 lbs 1620 27 One Over 120 lbs Administer the appropriate combination of tablets Administer TRIFEXIS with food for maximum effectiveness. If a dose is missed and a monthly interval between doses is exceeded, then immediate administration of TRIFEXIS with food and resumption of monthly dosing will minimize the opportunity for the development of adult heartworm infections and flea reinfestations. If vomiting occurs within an hour of administration, redose with another full dose. Heartworm Prevention: TRIFEXIS should be administered at monthly intervals beginning within 1 month of the dog's first seasonal exposure and continuing until at least 3 months after the dog's last seasonal exposure to mosquitoes (see EFFECTIVENESS ). TRIFEXIS may be administered year round without interruption. When replacing another heartworm preventative product, the first dose of TRIFEXIS should be given within a month of the last dose of the former medication. Flea Treatment and Prevention: Treatment with TRIFEXIS may begin at any time of the year, preferably starting one month before fleas become active and continuing monthly through the end of flea season. In areas where fleas are common year-round, monthly treatment with TRIFEXIS should continue the entire year wi Minimize