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Sedivet 1% Injection, 20 mL Vial Sedivet 1% Injection, 20 ... Read more

Sedivet 1% Injection, 20 mL Vial Sedivet 1% Injection, 20 mL Vial is used as a sedative and pain reliever to facilitate handling, restraint and minor surgical procedures in adult horses. Sedivet pet medications are also used as a preanesthetic prior to the induction of general anesthesia. Sedivet 1% Injection Horse Pain Reliever and Sedative Medication Sedative & Analgesic For Horses (romifidine hydrochloride) Sedivet 1.0% Injection is indicated for use as a sedative and analgesic to facilitate handling, clinical examinations, clinical procedures, and minor surgical procedures in adult horses. Sedivet 1.0% Injection is also indicated as a preanesthetic prior to the induction of general anesthesia in adult horses. Description: Sedivet 1.0% Injection (romifidine hydrochloride) is an a 2 -adrenoceptor agonist with sedative and analgesic properties. The chemical name is 2-bromo-6-fluoro-2-imidazolidinyliden-benzamine-monohydrochloride. It is a crystalline, white, odorless, water soluble substance with a molecular formula of C 9 H 9 BrFN 3 HCl, and a molecular weight of 294.56. Each mL contains 10 mg romifidine hydrochloride, 6.5 mg sodium chloride, 2 mg chlorocresol, and water for injection. Dosage and Administration: Sedation and Analgesia Dose: Administer slowly as a single IV injection using a dosage range of 40 - 120 g/kg (0.4 - 1.2 mL/100 kg body weight) depending on the depth and duration of sedation that is required. The onset of action occurs in 30 seconds to 5 minutes, and gradually subsides during the next 2 to 4 hours. Degree of sedation and analgesia is dose-and time-dependent; therefore, more profound analgesia will occur with larger doses, as well as closer to the time of injection. Note: The animal should be allowed to rest quietly for several minutes prior to and following injection. Note: The duration of analgesia is shorter than the duration of sedation. Sedation Dose Onset of Sedation Duration of Sedation Onset of Analgesia Duration of Analgesia 40 g/kg (0.4 mL/100 kg) 2-4 minutes 75 minutes 5 minutes 30 minutes 120 g/kg (1.2 mL/100 kg) 2-4 minutes 3 hours 5 minutes 150 minutes Preanesthesia Dose: A single IV injection using a dose of 100 g/kg (1.0 mL/100 kg body weight) was shown to be effective in the preanesthesia dose confirmation study (see Effectiveness). Anesthesia should be induced after maximum sedation is achieved. The administration of a 2 -agonists results in anesthetic sparing effects 1,2 ; therefore, anesthetic doses should be reduced to avoid overdose. Mild to moderate sedation occurs within 2-4 minutes. Following induction, lateral recumbency occurs within 4 minutes, followed by complete anesthesia within 6-16 minutes. During recovery from anesthesia, sternal recumbency occurs within 12-83 minutes, followed by standing in 17-84 minutes. Recovery time is primarily determined by the choice of induction anesthetic and/or the duration of anesthesia. Contraindications: Sedivet 1.0% Injection is contraindicated in horses with known hypersensitivity to romifidine. Intravenous potentiated sulfonamides should not be used in anesthetized or sedated horses as potentially fatal cardiac dysrhythmias may occur. Caution: Federal law restricts this drug to use by or on the order of a licensed veterinarian. Warnings: Not for human use. Keep this and all drugs out of the reach of children. Not for horses intended for human consumption. Although apparently deeply sedated, some horses may still respond to external stimuli with defensive movements (for example, kicking). Sedated horses are frequently ataxic. Routine safety measures should be used to protect practitioners and handlers. Romifidine hydrochloride can be absorbed and may cause irritation following direct exposure to skin, eyes or mouth. In case of accidental eye exposure, flush with water for 15 minutes. In case of accidental skin exposur Minimize